BloodCenter of Wisconsin, Blood Research Institute, Milwaukee, WI, USA. Medical College of Wisconsin, Department of Medicine, Division of Hematology and Oncology, Milwaukee, WI, USA. Department of Anesthesia and Pain Management, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada. Department of Surgery and Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA. University of Alberta, Department of Pediatrics, Edmonton, Alberta, Canada.